Thursday, February 21, 2008

eponyms in medicine - part 22

211 - Eagle effect is failure of penicillin in streptococcal infection when bacteria aren’t growing - i.e. - beta-lactams being more effective against rapidly growing bacteria in the early stages and less effective as bacterial growth slows (described by Eagle in 1952).

212 - Ortner’s syndrome is hoarseness from compression of left recurrent laryngeal nerve by a greatly dilated left atrium (e.g. - in mitral stenosis) - enlarged tracheobronchial lymph nodes - and dilated pulmonary artery.

213 - Weber test is 512 Hz tuning fork placed on patients’s forehead; sound localizes towards side with conductive hearing loss; localizes away from the side with soensorineural loss.

214 - Hering - canals of is at the fringes of the portal tract - from the joining of bile canaliculi.

215 - Pott’s disease is tuberculous involvement of the spine; occurs in about 2% of TB cases.

216 - Hunter’s syndrome is mucopolysaccharidosis (II) - iduronate sulfatase deficiency - X-linked - affecting degradation of dermatan sulfate and heparan sulfate - resulting in physical deformity and mental retardation - no corneal clouding.Hunter syndrome is A syndrome with variable manifestations exhibiting mainly microcephaly characteristic facies mental retardation short stature acral skeletal anomalies with occasional craniosynostosis and congenital heart defects.

217 - Imerslund-Grasbeck syndrome is juvenile megaloblastic anemia - an autosomal recessive condition involving mutation in cubulin - receptor that binds IF-B12 complex; also associated with proteinuria.

218 - Jerusalem syndrome is psychosis affecting visitors to Jeruasalem whereby afflicted develop psychotic religious delusions; affects a handful of visitors each year.

219 - Archibald’s sign is in pseudohypoparathyroidism of Albert’s hereditary osteodystrophy - characteristic shortening of the fourth and fifth digits as dimpling over the knuckles of a clenched fist.

220 - Susac syndrome is microangiopathy of the inner ear - retina - and brain leading to deafness - retinal artery occlusion - and encephalopathy.

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